Pmec 1% Cream | Pimecrolimus 1%
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Pmec 1% Cream | 10g Tube

Generic: Pimecrolimus

Type: Tube

Pack Size: 1 Pc

Pmec Cream (not indicated for children under 2 years of age) is recommended as a second-line treatment for short-term and intermittent long-term management of mild to moderate atopic dermatitis in non-immunocompromised adults and children aged 2 years and above, who have not responded adequately to other topical prescription therapies, or when those treatments are unsuitable.

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✅ Description:

Pimecrolimus is a macrolactam derivative of ascomycin and belongs to the class of topical immunosuppressants. It works by inhibiting T-cell activation and reducing the release of inflammatory mediators from mast cells.

Although the exact mechanism of atopic dermatitis is not fully understood, studies show that:

  • Pimecrolimus binds with high affinity to FKBP-12 (macrophilin-12).
  • It blocks calcineurin activity, thereby suppressing transcription of early cytokines.
  • It inhibits both Th1 (IL-2, IFN-γ) and Th2 (IL-4, IL-10) cytokine synthesis.
  • It prevents antigen/IgE-induced release of pro-inflammatory mediators from mast cells.
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✔️ Side Effects | Pmec
  • Common: headache, cold, sore throat, cough, flu, fever, viral infections.
  • Possible: viral skin infections (e.g., cold sores, chickenpox, shingles, warts), swollen lymph nodes.
✔️ Dosage & Administration | Pmec
  • Apply a thin layer twice daily to the affected skin.
  • Discontinue once symptoms such as itching, redness, and rash subside.
  • If symptoms recur, patients should be instructed on the appropriate next steps.
  • If no improvement is seen after 6 weeks, a healthcare provider should reassess the diagnosis.
  • Continuous long-term use should be avoided; apply only to affected areas.
  • Safety under occlusive dressings has not been established; avoid such use.
✔️ Interaction

Potential drug interactions have not been fully evaluated.

Due to minimal systemic absorption, significant interactions are unlikely but cannot be ruled out.

Use with caution in patients with extensive or erythrodermic disease when co-administered with CYP3A inhibitors (e.g., erythromycin, itraconazole, ketoconazole, fluconazole, calcium channel blockers, cimetidine).

✔️ Contraindications

Known hypersensitivity to pimecrolimus or any component of the cream.

✔️ Pregnancy & Lactation

Pregnancy Category C: No adequate, controlled studies in pregnant women. Use only if the benefits outweigh the risks.

Unknown if excreted in breast milk; risk to nursing infants cannot be excluded. A decision should be made to either discontinue the drug or breastfeeding, depending on clinical need.

✔️ Precautions & Warnings
  • Not for use in immunocompromised patients or those on systemic immunosuppressants.
  • Avoid applying to malignant or pre-malignant skin lesions.
  • Not recommended in patients with Netherton’s Syndrome or other skin conditions that may increase systemic absorption.
✔️ Storage:

Store below 30°C, away from light and moisture. Keep out of reach of children.

Frequently Asked Questions (FAQ)

Pmec 1% Cream is used to treat swelling, redness, and itching caused by skin conditions such as dermatitis and eczema.

Do not apply to sunburns, open wounds, blisters, or infected areas. Avoid contact with eyes, nose, mouth, or genitals (rinse thoroughly with water if contact occurs). Avoid shingles, chickenpox, or measles exposure while using this cream; inform your doctor immediately if exposed.

No. Do not stop taking this medication without consulting your doctor. Stopping too soon may cause symptoms to return or worsen.

Apply it as soon as you remember. If it’s nearly time for your next dose, skip the missed one. Do not apply extra cream to make up for a missed dose.

No. Pmec 1% Cream is a prescription-only medicine.

Use it only for the duration prescribed. If your symptoms do not improve or worsen after 1 week, consult your doctor.

Pmec 1% Cream contains Pimecrolimus, an immunosuppressant. It works by suppressing the immune response in the skin, which helps reduce inflammation and eczema symptoms.

Yes, studies show it is safe and effective for both young and elderly patients.

Wash and dry the affected area before applying. Take a small amount on your fingertip and apply a thin layer. Rub it in gently. Wash your hands before and after applying (unless your hands are being treated). Do not cover with dressings or bandages unless instructed by your doctor.

Yes, but only if prescribed by your doctor. Do not use it for more than 5 days on the face, as the skin there is more delicate.

No, Pmec 1% Cream is not a steroid. It is an immunosuppressant.
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⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

📦Pricing Information, Availability:
Product Availability & Pricing Notice Please note that pricing, availability, and service offerings are subject to change due to: Market fluctuations, Manufacturer or supplier adjustments, Product discontinuation or temporary unavailability, Advertising errors. All orders depend on stock availability and staff resources. If services are provided on a time-and-materials basis, any shared estimates are for planning purposes only.

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